Inhaled nitric oxide and exercise capacity in congestive heart failure
1997; Elsevier BV; Volume: 349; Issue: 9057 Linguagem: Inglês
10.1016/s0140-6736(05)62897-8
ISSN1474-547X
AutoresAkihiro Matsumoto, Shin‐ichi Momomura, Yasunobu Hirata, Teruhiko Aoyagi, Seiryo Sugiura, Masao Omata,
Tópico(s)Heart Failure Treatment and Management
ResumoPatients with congestive heart failure (CHF) often have pulmonary congestion, which causes ventilation-perfusion mismatch and leads to shallow and rapid ventilation. Although vasodilators, such as nitrates, improve pulmonary hypertension, they do not improve exercise tolerance, 1 Franciosa JA Cohn JN Effect of isosorbide dinitrate on response to submaximal and maximal exercise in patients with congestive heart failure. Am J Cardiol. 1979; 43: 1009-1014 Summary Full Text PDF PubMed Scopus (62) Google Scholar probably because they further aggravate the ventilation-perfusion mismatch. Inhaled nitric oxide (NO) has been used to treat patients with primary pulmonary hypertension 2 Pepke-Zaba J Higenbottam TW Dinh-Xuan AT Stone D Wallwork J Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet. 1991; 338: 1173-1174 Summary PubMed Scopus (963) Google Scholar or CHF. 3 Semigran MJ Cockrill BA Kacmarek R et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol. 1994; 24: 982-988 Summary Full Text PDF PubMed Scopus (186) Google Scholar We investigated whether inhaled NO increases exercise capacity in patients with CHF.
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