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Controlling and Coordinating Development in Vector-Transmitted Parasites

2011; American Association for the Advancement of Science; Volume: 331; Issue: 6021 Linguagem: Inglês

10.1126/science.1198077

1095-9203

Keith R. Matthews,

Research on Leishmaniasis Studies

Vector-borne parasites cause major human diseases of the developing world, including malaria, human African trypanosomiasis, Chagas disease, leishmaniasis, filariasis, and schistosomiasis. Although the life cycles of these parasites were defined over 100 years ago, the strategies they use to optimize their successful transmission are only now being understood in molecular terms. Parasites are now known to monitor their environment in both their host and vector and in response to other parasites. This allows them to adapt their developmental cycles and to counteract any unfavorable conditions they encounter. Here, I review the interactions that parasites engage in with their hosts and vectors to maximize their survival and spread.