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Clinical outcomes in children with hyoscyamus niger intoxication no receiving physostigmine therapy

2007; Lippincott Williams & Wilkins; Volume: 14; Issue: 6 Linguagem: Inglês

10.1097/mej.0b013e328122de2f

1473-5695

Hakan Döneray, Zerrin Orbak, Cahit Karakelleoğlu,

Drug-Induced Hepatotoxicity and Protection

Diagnosis of hyoscyamus niger intoxication is based on clinical symptomatology and history. Therapy includes stomach lavage, supportive therapy, and physostigmine as a specific antidote. Physostigmine is not available in Turkey. This retrospective study investigated the clinical outcomes in children with hyoscyamus niger intoxication who did not receive physostigmine therapy.Twenty-three children whose history and medical records indicated hyoscyamus niger intoxication were included the study.None of the cases had any abnormal laboratory findings. All the patients were performed gastric lavage and provided with supportive therapy. None of the children had any complications, and none required mechanical ventilation or died. All the patients were discharged in good health within 48 h.Our findings suggest that hyoscyamus niger intoxication in children is self-terminating and responds to supportive therapy and that routine use of physostigmine is unnecessary in every case with hyoscyamus niger intoxication.