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Anabolic Resistance of Muscle Protein Synthesis with Aging

2013; Lippincott Williams & Wilkins; Volume: 41; Issue: 3 Linguagem: Inglês

10.1097/jes.0b013e318292f3d5

1538-3008

Nicholas A. Burd, Stefan H.M. Gorissen, Luc J. C. van Loon,

Sports Performance and Training

In Brief Aging has been associated with a reduced muscle protein synthetic response to protein intake, termed “anabolic resistance.” Physical activity performed before protein intake increases the use of protein-derived amino acids for postprandial muscle protein accretion in senescent muscle. Thus, the level of habitual physical activity may be fundamental to maintain the anabolic responsiveness to protein intake with aging. We provide evidence to suggest that maintenance of physical activity can reduce the anabolic resistance of muscle protein synthesis to protein intake with aging.