High Throughput Kinetic Investigations of Asymmetric Hydrogenations with Microdevices
2003; Wiley; Volume: 345; Issue: 1-2 Linguagem: Inglês
10.1002/adsc.200390010
ISSN1615-4169
AutoresClaude de Bellefon, N. Pestre, Thierry Lamouille, Pierre Grenouillet, Volker Hessel,
Tópico(s)Innovative Microfluidic and Catalytic Techniques Innovation
ResumoAbstract A high throughput test which is based on a micromachined mixer for molecular gas‐liquid reactions was evaluated for the kinetic investigation of the asymmetric hydrogenation of methyl Z‐(α)‐acetamidocinamate with a rhodium/( S,S ‐BDPPTS) catalyst in an aqueous phase. Up to 214 tests were performed in a short time and with an average inventory of Rh/test as low as 14 μg. Comparisons with traditional batch experiments are provided.
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