Synthesis and properties of a novel fluorescent nucleobase, naphthopyridopyrimidine
2003; Elsevier BV; Volume: 44; Issue: 36 Linguagem: Inglês
10.1016/s0040-4039(03)01740-4
ISSN1873-3581
AutoresAkimitsu Okamoto, Kazuki Tainaka, Isao Saito,
Tópico(s)HIV/AIDS drug development and treatment
ResumoA new base-discriminating fluorescent nucleoside, NPP, that can sharply distinguish between A and G bases opposite NPP is described. The hybridization of an ODN probe containing NPP with a target DNA facilitates the judgment of the type of purine base located at a specific site on the target DNA.
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