Multi-component nanorods for vaccination applications
2005; IOP Publishing; Volume: 16; Issue: 4 Linguagem: Inglês
10.1088/0957-4484/16/4/025
ISSN1361-6528
AutoresAliasger K. Salem, Chien‐Fu Hung, T W Kim, T.‐C. Wu, Peter C. Searson, Kam W. Leong,
Tópico(s)Monoclonal and Polyclonal Antibodies Research
ResumoImmune responses from Au/Ni nanorods prepared by electrochemical deposition in alumina templates are evaluated in C57BL/6 mice. When the nanorods are bombarded into skin, they generate a strong CD8 T-cell and antibody response. When pcDNA3 is bound to the Ni segment of the nanorod, it provides a strong immunostimulatory adjuvant effect to the antigen bound on the Au segment.
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