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Implantes de biomateriais em falha óssea produzida na fíbula de ratos

2010; Thieme Medical Publishers (Germany); Volume: 45; Issue: 5 Linguagem: Inglês

10.1590/s0102-36162010000500017

1982-4378

Henrique Yassuhiro Shirane, Diogo Yochizumi Oda, Thiago Cerizza Pinheiro, Marcelo Rodrigues da Cunha,

Bone Tissue Engineering Materials

Objective: To evaluate the importance of collagen and hydroxyapatite in the regeneration of fractures experimentally induced in the fibulas of mice.Method: 15 rats were submitted to a surgery for the removal of a fragment of the fibula.The fragment was replaced by a silicone tube filled with hydroxyapatite and collagen.Results: Little bone neoformation occurred inside the tubes filled with biomaterials, the largest amount occurring in those with collagen.Conclusion: The biomaterials used demonstrated biocompatibility and osteoconductive capacity capable of stimulating osteogenesis, even in bones with secondary mechanical and morphological functions such as the fibula of the rat.