Effect of Testosterone on the Glycolic Acid Oxidase Levels in Male and Female Rat Liver
1964; Oxford University Press; Volume: 74; Issue: 1 Linguagem: Inglês
10.1210/endo-74-1-128
ISSN1945-7170
Autores Tópico(s)Metabolism and Genetic Disorders
ResumoThe liver levels of glycolic acid oxidase and a-hydroxy acid oxidase were approximately 30% higher in adult male rats than in adult female rats. However, no sex difference in enzyme levels occurred until after puberty. No sex-related difference in liver levels was observed with either aldehyde oxidase or xanthine oxidase. The latter, however, was not detected in either male or female rat liver until 19 days after birth. Castration of adult male rats caused a drop in liver levels of glycolic acid oxidase and α-hydroxy acid oxidase, but had no effect on xanthine oxidase and aldehyde oxidase levels. Subcutaneous administration of testosterone (0.1 mg/100 g rat wt) to castrated adult male rats significantly maintained their glycolic acid oxidase levels. Prepuberty castration of male rats prevented the induction of glycolic acid oxidase. This effect was not reversed by subcutaneous administration of testosterone (0.1 mg/100 g rat wt). Castration of adult female rats had no effect on the liver levels of the enzymes investigated. The results obtained are discussed with respect to the higher resistance of female rats to the toxic effects of glycolic acid and ethylene glycol. (Endocrinology74: 128, 1964)
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