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BIBTEX RIS

012 — (CAM0047) Previous aerobic exercise program does not alter seizure susceptibility in adult female rats

2014; Elsevier BV; Volume: 38; Linguagem: Inglês

10.1016/j.yebeh.2014.08.045

1525-5069

Diego Vannucci Campos, Alexandre Aparecido de Almeida, Ricardo Mário Arida, Luiz Guilherme Zaccaro do Amaral Baliego, Ésper A. Cavalheiro, Jansen Fernandes, S. Gomes da Silva, Glauber Menezes Lopim, Adriano Fortes Maia, Débora Amado, Fúlvio A. Scorza,

Epilepsy research and treatment

Rationale: Although recent studies have shown the importance of physical activity on seizure frequency and severity in both men and male animals with epilepsy, this effect in women and female rats remains unexplored. The female contingent deserves special attention because of the hormonal alterations related to the estrous cycle. Endocrine and reproductive alterations are frequently reported to occur in women with temporal lobe epilepsy as well as in female rats in different experimental models of limbic seizures. Several studies have suggested an association between seizure susceptibility and estrogen/progesterone ratio, showing a decreased number of seizures during the luteal phase, when progesterone concentration is highest. Besides, several authors have observed a high frequency of anovulatory cycles or inadequate luteal phase in women with epilepsy. Considering the reported data about the influence of physical activity programs over the epileptogenic process and epilepsy, we aimed to assess whether an aerobic physical activity program may alter seizure susceptibility to subsequent pilocarpine insult.