Asymmetric synthesis of chiral, Nonracemic dialkyl-α-hydroxyalkylphosphonates via a (−)-Chlorodiiso-pinocampheylborane (Ipc2B-Cl) reduction
1996; Elsevier BV; Volume: 7; Issue: 1 Linguagem: Inglês
10.1016/0957-4166(95)00424-6
ISSN1362-511X
AutoresChris Meier, Wolfgang H.G. Laux,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoThe enantioselective synthesis of dialkyl α-hydroxybenzylphosphonates 2 using a (−)-chlorodiisopinocampheylborane (Ipc2B-Cl) 3 catalyed reduction starting with α-keto-phosphonates 1 is described. The reaction gave the target compounds 2 in good yields with predictable stereochemistry and enantiomeric excesses up to 65% ee.
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