Dietary linoleic acid affects phospholipid fatty acid composition in heart and eicosanoid production by cardiomyocytes from atlantic salmon (Salmo salar)
1992; Elsevier BV; Volume: 103; Issue: 2 Linguagem: Inglês
10.1016/0300-9629(92)90591-d
ISSN0300-9629
AutoresJ. Gordon Bell, James R. Dick, J. R. Sargent, Alasdair H. McVicar,
Tópico(s)Fatty Acid Research and Health
Resumo1. Atlantic salmon post-smolts were fed practical-type diets containing linoleic acid at 10, 25 or 45% of total dietary fatty acids for a period of 20 weeks. 2. As dietary linoleic acid was increased, individual phospholipids of heart contained increased levels of 18:2n-6, 20:2n-6, 20:3n-6 and 20:4n-6 and reduced levels of 20:5n-3. The ratio of n-3/n-6 polyunsaturated fatty acids in heart phospholipids decreased and the ratio of 20:4n-6/20:5n-3 increased. 3. An increased production of thromboxane B2 occurred in isolated cardiac myocytes from fish given the highest dietary linoleic acid but the production of 6-keto prostaglandin F1α was not significantly affected, nor was the activity of heart sarcoplasmic reticulum Ca2+-Mg2+ ATPase (EC 3.6.1.4).
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