Portal de Periódicos da CAPES

The effect of renal denervation on endothelial function and inflammatory markers in patients with resistant hypertension

2015; Elsevier BV; Volume: 188; Linguagem: Inglês

10.1016/j.ijcard.2015.04.041

1874-1754

Nina Eikelis, Dagmara Hering, Petra Marušić, Carolina I. Sari, Antony Walton, Sarah Phillips, Élisabeth Lambert, J Duval, Henry Krum, Gavin Lambert, Murray D. Esler, Markus P. Schlaich,

Sodium Intake and Health

Hypertension is an important risk factor in the development and progression of cardiovascular disease. Renal denervation (RDN) has been shown to reduce blood pressure (BP) and muscle sympathetic nerve activity in patients with resistant hypertension (RH) [ 1 Krum H. Schlaich M. Whitbourn R. et al. Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study. Lancet. 2009; 373: 1275-1281 Abstract Full Text Full Text PDF PubMed Scopus (1763) Google Scholar , 2 Symplicity H.T.N.I. Esler M.D. Krum H. et al. Renal sympathetic denervation in patients with treatment-resistant hypertension (the Symplicity HTN-2 trial): a randomised controlled trial. Lancet. 2010; 376: 1903-1909 Abstract Full Text Full Text PDF PubMed Scopus (1851) Google Scholar ]. Irrespective of the effects of RDN on BP, there is little data to date to describe the impact of this procedure on other systems and organs.