Abnormal hematopoieses in 2 of 3 siblings with mongolism
1966; Elsevier BV; Volume: 68; Issue: 4 Linguagem: Inglês
10.1016/s0022-3476(66)80395-5
ISSN1097-6833
AutoresRichard E. Behrman, Arnold T. Sigler, A.S. Patchefsky,
Tópico(s)Erythrocyte Function and Pathophysiology
ResumoIn a family with 3 siblings who had mongolism, 2 of them presented as newborninfants with thrombocytopenia and marked aberrations in the regulation of both erythropoiesis and leukopoiesis. Karyotypes of each of these children revealed a 15/21 translocation. At postmortem examination, one infant had widespread infiltrates of cells such as may be seen in chronic myelocytic leukemia. It is postulated that the regulation of the development of a wide variety of cellular elements in blood is affected in these children. In a family with 3 siblings who had mongolism, 2 of them presented as newborninfants with thrombocytopenia and marked aberrations in the regulation of both erythropoiesis and leukopoiesis. Karyotypes of each of these children revealed a 15/21 translocation. At postmortem examination, one infant had widespread infiltrates of cells such as may be seen in chronic myelocytic leukemia. It is postulated that the regulation of the development of a wide variety of cellular elements in blood is affected in these children. ErratumThe Journal of PediatricsVol. 69Issue 1Preview Full-Text PDF
Referência(s)