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Artigo Revisado por pares
BIBTEX RIS

Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies

2005; Lippincott Williams & Wilkins; Volume: 65; Issue: 5 Linguagem: Inglês

10.1212/01.wnl.0000174517.21383.36

ISSN

1526-632X

Autores

A. Crespel, Pierre Genton, M. Berramdane, Philippe Coubes, C. Monicard, M Baldy-Moulinier, Philippe Gélisse,

Tópico(s)

Glycogen Storage Diseases and Myoclonus

Resumo

Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.

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