Protein Nanocapsule Weaved with Enzymatically Degradable Polymeric Network
2009; American Chemical Society; Volume: 9; Issue: 12 Linguagem: Inglês
10.1021/nl902935b
ISSN1530-6992
AutoresZhen Gu, Ming Yan, Biliang Hu, Kye‐Il Joo, Anuradha Biswas, Yu Huang, Yunfeng Lu, Pin Wang, Yi Tang,
Tópico(s)Advanced Proteomics Techniques and Applications
ResumoTarget proteins can be functionally encapsulated using a cocoon-like polymeric nanocapsule formed by interfacial polymerization. The nanocapsule is cross-linked by peptides that can be proteolyzed by proteases upon which the protein cargo is released. The protease-mediated degradation process can be controlled in a spatiotemporal fashion through modification of the peptide cross-linker with photolabile moieties. We demonstrate the utility of this approach through the cytoplasmic delivery of the apoptosis inducing caspase-3 to cancer cells.
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