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Reference Data of the Main Physiological Parameters in Control Sprague-Dawley Rats from Pre-clinical Toxicity Studies

2010; BioMed Central; Volume: 26; Issue: 2 Linguagem: Inglês

10.5625/lar.2010.26.2.153

2233-7660

Zhong-Ze Han, Hong-De Xu, Kwang Ho Kim, Tae-Hwan Ahn, Jin-Sook Bae, Ji-Young Lee, Ki-Hyun Gil, Joo-Young Lee, Su-Jung Woo, Hyun‐Jung Yoo, Hyun-Kul Lee, Kap-Ho Kim, Chan-Koo Park, Hu-Song Zhang, Si-Whan Song,

Toxic Organic Pollutants Impact

The purpose of this paper is to provide reference data related to the body weight, food & water consumptions, urinalysis, hematology and serum biochemistry parameters and absolute & relative organ weights obtained from control Sprague-Dawley rats, used in the 4-week and 13-week repeated-dose toxicity studies conducted in our laboratory between 2005 and 2008. The mean, standard deviation, minimum and maximum range values for hematology and serum biochemistry parameters, data of absolute & relative organ weights, and the difference between sexes and study duration of week 4 versus 13 week are presented. The studies were conducted according to "the standards of Toxicity Study for Medicinal Products" (2005) and The KFDA Notification No. 2000-63 'Good Laboratory Practice (GLP)' (2000) issued by KFDA. These data could be used as reference material of Sprague-Dawley rats by conducting the studies to evaluate the toxicological profile of pre-clinical toxicity studies.