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Primary cutaneous anaplastic large-cell lymphoma - case report

2013; Elsevier BV; Volume: 88; Issue: 6 suppl 1 Linguagem: Inglês

10.1590/abd1806-4841.20131731

1806-4841

Luciana Silveira Rabello de Oliveira, Madeleyne Palhano Nobrega, Maíra Gomes Monteiro, Wagner Leite de Almeida,

Lymphoma Diagnosis and Treatment

Primary cutaneous anaplastic large-cell lymphoma is part of the spectrum of CD30+ lymphoproliferative cutaneous processes, characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. Extracutaneous dissemination may occur, especially to regional lymph nodes. Histology shows a diffuse, non-epidermotropic infiltrate , anaplastic large lymphoid cells of immunohistochemistry CD30+, CD4+, EMA-/+, ALK-, CD15- and TIA1-/+. Prognosis is good and does not depend on lymphatic invasion. Radiotherapy, removal of the lesion and/or low-dose methotrexate are the treatments of choice. The present study reports the case of a 57-year-old-woman presenting Primary cutaneous anaplastic large-cell lymphoma with multifocal lesions. The pacient evolved with pulmonary involvement 7 years later. She showed a good response to the treatment with low-dose methotrexate prescribed weekly.