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New compressed tablet rapidly disintegrating in saliva in the mouth using crystalline cellulose and a disintegrant.

1995; Pharmaceutical Society of Japan; Volume: 18; Issue: 9 Linguagem: Inglês

10.1248/bpb.18.1308

1347-5215

Yoshiteru Watanabe, Kei-ichi Koizumi, Yoshiko ZAMA, Miyuki Kiriyama, Yoshiaki Matsumoto, Mitsuo Matsumoto,

Digestive system and related health

We formulated a new compressed tablet which is rapidly disintegrated and dissolved in the mouth without the need to drink water. The crushing strength increased with increasing compression force and maximum values (8-18 kgf) for the formulations comprising crystalline cellulose and low-substituted hydroxypropylcellulose (L-HPC) were obtained at the compression force of 300 kgf. Rapid disintegration (within 30 s) was obtained in vitro using various compounding ratios of crystalline cellulose to L-HPC. Tablets prepared with crystalline cellulose and L-HPC rapidly disintegrated in saliva (small amount of water) in the mouth of humans.