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Characterization of a Novel Polycystic Kidney Rat Model with Accompanying Polycystic Liver.

2000; Volume: 49; Issue: 1 Linguagem: Inglês

10.1538/expanim.49.51

1884-4170

Makoto Katsuyama, Takeshi Masuyama, Ichirō Kōmura, Tsutomu Hibino, Hisahide Takahashi,

Renal and related cancers

A polycystic kidney rat model is being established from a Crj:CD (SD) rat strain. Unlike existing animal models of polycystic kidney disease, this mutant rat has a completely polycystic liver. Mating experiments revealed that the phenotype is controlled by an autosomal recessive gene. We propose that this gene be tentatively called the "rpc" gene.