Glycine-like immunoreactivity in synaptic boutons of identified inhibitory interneurons in the mammalian spinal cord
1991; Elsevier BV; Volume: 547; Issue: 1 Linguagem: Inglês
10.1016/0006-8993(91)90590-r
ISSN1872-6240
Autores Tópico(s)Sleep and Wakefulness Research
ResumoGlycine is thought ti be a major inhibitory neurotransmitter in the mammalian CNS. Two types of physiologically identified interneurons, Renshaw cells and Ia inhibitory interneurons, were intracellularly staind with horseradish peroxidase, and their axon terminals were studied at the electron microscopic level. Post-embedding immunogold procedures weer used to reveal the presence of glycine-like immunoreactivity. The synaptic terminals of both types of interneuron were significantly enriched with glycine-like immunoreactivity, providing support for the idea that glycine is a mediator of synaptic transmission in the recurrent and reciprocal inhibitory pathways to motoneurons.
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