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Transcriptional repression in development

1996; Elsevier BV; Volume: 8; Issue: 3 Linguagem: Inglês

10.1016/s0955-0674(96)80010-x

1879-0410

Susan Gary, Michael Levin,

RNA Research and Splicing

It is becoming increasingly clear that transcriptional repression is at least as important as transcriptional activation for establishing cell-type specific patterns of gene expression during embryogenesis. Recent studies in Drosophila suggest that repressors fall into two categories, short-range and long-range repressors. The former permit enhancer autonomy in modular promoters, whereas the latter function in a dominant fashion to silence multiple enhancers.