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A long-term survey of morphine in cancer pain patients

1992; Elsevier BV; Volume: 7; Issue: 5 Linguagem: Inglês

10.1016/0885-3924(92)90059-q

1873-6513

Stephan A. Schug, D. Zech, Stefan Grond, Helena Jung, Thomas Meuser, B. Stobbe,

Pharmacological Effects and Toxicity Studies

We survged 550 cancer patients who ex@enced pain and were treated rarith mo$hine for a total of 22,525 beatment day.Su@ient pain re&$was achiared duriq more than 80% of this time using an auerage oral morphine dose of 82.4 ~sign$cantiy lower than other studies.Ihe use of this 10~ dose, which was possible due to the concomitant administration of nonopioids and specijic coana&ics in most patients, rexdted in a low incia!ence of side @ecti.Con.&pation and nausea/vomiting were the most common of these side @ecti.Phy35cal depena%nce posed no praclical probhm in discontinuation of morphine treatment.Long-d opioid intake and development of tolerance did not appear to be linked; an increase ilz morphine dosage was most oji!en explained by progression of the terminal diseare.Addiction was a negl&bleproblem, with only one tjbserved case.J Pain Symptom Manage 1992; 7:2.59-266.