Portal de Periódicos da CAPES

Chemoselective Peptide Ligation–Desulfurization at Aspartate

2013; Wiley; Volume: 52; Issue: 37 Linguagem: Inglês

10.1002/anie.201304793

1521-3773

Robert E. Thompson, Bun Chan, Leo Radom, Katrina A. Jolliffe, Richard J. Payne,

Peptidase Inhibition and Analysis

Asp-ecially useful: A synthetic β-mercapto aspartate residue facilitates the rapid ligation to a range of peptide thioesters. Following the ligation reaction (and without purification), chemoselective desulfurization of the β-mercapto moiety in the presence of unprotected cysteine residues afforded native peptide products.