Effects of protein synthesis inhibition on kindling in the mouse
1980; Elsevier BV; Volume: 68; Issue: 3 Linguagem: Inglês
10.1016/0014-4886(80)90097-7
ISSN1090-2430
AutoresDonald P. Cain, Michael E. Corcoran, William A. Staines,
Tópico(s)Epilepsy research and treatment
ResumoMice treated with anisomycin during amygdaloid kindling failed to develop generalized seizures. Anisomycin failed to suppress fully developed seizures in kindled mice, indicating that its prophylactic effects are not secondary to a general anticonvulsant action. These results are consistent with the hypothesis that the central neuroplastic changes underlying kindling require the ongoing synthesis of proteins.
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