Theoretic Effects of Mucus Gland Discharge on Airway Resistance in Asthma
1995; Elsevier BV; Volume: 107; Issue: 3 Linguagem: Inglês
10.1378/chest.107.3_supplement.110s
ISSN1931-3543
Autores Tópico(s)Inhalation and Respiratory Drug Delivery
ResumoThe degree to which mucus contributes to airway narrowing and increased airway resistance in fatal asthma was examined in this study. Lungs obtained at coroner's autopsy were fixed at 25 cm H2O. Cases were classified as control (no history of asthma), nonfatal (previous history of asthma with sudden death not due to asthma attack), or fatal (died of asthma attack). On transverse sections of cartilaginous airways the inner wall area (WAi) from lumen to smooth muscle layer, internal perimeter (Pi), and area of mucus glands (Agland) were measured. Relative wall area (PW) was calculated; PW=WAi/(Pi2/4π+WAi), where Pi2/4π is the relaxed airway lumen area. Agland was expressed as a percent of Pi2/4π to give the theoretic maximal mucus occupying ratio (MOR) and the additive effects of mucus to wall thickness (PW) on airway resistance (Raw) at 0, 20, and 40% muscle shortening (PMS) were calculated using the formulations of Moreno et al. 1 Moreno RH Hogg JC Paré PD Mechanics of airway narrowing. Am Rev Respir Dis. 1986; 133: 1171-1180 PubMed Google Scholar
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