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Is there a role for pre-operative thrombocytosis in the management of colorectal cancer?

2010; Wolters Kluwer; Volume: 8; Issue: 6 Linguagem: Inglês

10.1016/j.ijsu.2010.05.005

1743-9191

S. M. Nyasavajjala, Francois Runau, Sayan Datta, Haines Annette, Aidan Shaw, Jonathan N. Lund,

Venous Thromboembolism Diagnosis and Management

High circulating platelet counts have been associated with poor prognosis in a variety of solid tumours such as breast, renal and lung cancer. We investigated the significance of a high pre-operative platelet count on overall survival in patients with stages I–IV colorectal cancer. 630 Consecutive patients who colorectal cancer resection between 2004 and 2007 with a full blood count taken 14 days prior to the surgery were assessed. Male:female 7:5, median (range) age 73 (40–99 years). Thrombocytosis was defined as platelet count of ≥450 × 109/L. The relationship between platelet count, pathological features and overall survival was assessed. : Mantel–Cox regression showed that platelet count does not predict survival on multivariate analysis (p = 0.067). Thrombocytosis was present in 51/627 (8.1%) of cases. There was no statistically significant difference in mean survival (p = 0.067) observed in patients with platelet count <450 × 109/L (n = 576; 95%CI: 1550.5–1405.4 SE 37.0) versus ≥450 × 109/L (n = 51, CI: 1261.6–955.0, SE 78.2). There was also no correlation between Dukes stage and thrombocytosis. In our study, pre-operative thrombocytosis is not a prognostic indicator of survival in colorectal cancer patients regardless of pathological stage.