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Molecular Docking and Panicolytic Effect of 8-Prenylnaringenin in the Elevated T-Maze

2014; Pharmaceutical Society of Japan; Volume: 62; Issue: 12 Linguagem: Inglês

10.1248/cpb.c14-00569

1347-5223

Mariane Cristóvão Bagatin, Camila Santos Suniga Tozatti, Layara Akemi Abiko, Diego Alberto dos Santos Yamazaki, Priscila Rebeca Alves Silva, Leonardo Martins Perego, Elisabeth Aparecida Audi, Flávio Augusto Vicente Seixas, Ernani A. Basso, Gisele F. Gauze,

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The purpose of this study was to investigate the effects of the chronic administration of a racemic mixture of 8-prenylnaringenin (8-PN) on rats submitted to the elevated T-maze (ETM) model of generalized anxiety and panic disorders. The selective serotonin (SERT) reuptake inhibitor fluoxetine was used as a positive control. Rat locomotion was assessed in a circular arena following each drug treatment. The administration of racemic 8-PN for 21 d in rats increased one-way escape latencies from the ETM open arm, indicating a panicolytic effect. To evaluate the interactions of 8-PN with monoamine transporters, a docking study was performed for both the R and S configurations of 8-PN towards SERT, norepinephrine (NET) and dopamine transporters (DAT). The application of the docking protocol showed that (R)-8-PN provides greater affinity to all transporters than does the S enantiomer. This result suggests that enantiomer (R)-8-PN is the active form in the in vivo test of the racemic mixture.