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A linkage study of schizophrenia with DNA markers from chromosome 8p21-p22 in 25 multiplex families

1996; Elsevier BV; Volume: 22; Issue: 1 Linguagem: Inglês

10.1016/0920-9964(96)00048-5

1573-2509

Hiroshi Kunugi, David Curtis, Homero Vallada, Shin Nanko, John Powell, Robin M. Murray, Peter McGuffin, Michael J. Owen, Michael Gill, David Collier,

Genomic variations and chromosomal abnormalities

Two recent genome-wide searches for linkage (Lasseter et al., 1994; Moises et al., 1995) suggested that a susceptibility gene for schizophrenia might be located at chromosome 8p21-p22. We attempted to replicate these findings by performing a linkage study of schizophrenia with four DNA markers from this region using 25 multiply affected families. Neither the lod score method nor non-parametric extended sib-pair analysis yielded any evidence for linkage, even under the assumption of locus heterogeneity. We conclude that there is unlikely to be a major gene in the 8p21-p22 region which confers susceptibility to schizophrenia in our set of families. However we cannot exclude the possibility of a major gene present in other families, or of a susceptibility gene with a moderate but widespread effect which we cannot detect.