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Granulocyte colony stimulating factor-producing tongue carcinoma

1997; Wiley; Volume: 19; Issue: 4 Linguagem: Inglês

10.1002/(sici)1097-0347(199707)19

1097-0347

Arata Horii, Kazuo Shimamura, Yuichiro Honjo, Kenji Mitani, Tomohiro Miki, Shodayu Takashima, Junichi Yoshida,

Acute Myeloid Leukemia Research

Head & NeckVolume 19, Issue 4 p. 351-356 Case Report Granulocyte colony stimulating factor-producing tongue carcinoma Arata Horii MD, Corresponding Author Arata Horii MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanDepartment of Otolaryngology, Osaka University MEdical School, 2-2 Yamadaoka, Suita, Osaka 565, JapanSearch for more papers by this authorKazuo Shimamura MD, Kazuo Shimamura MD Department of Pathology, Tokai University School of Medicine, Kanagawa, JapanSearch for more papers by this authorYuichiro Honjo MD, Yuichiro Honjo MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanSearch for more papers by this authorKenji Mitani MD, Kenji Mitani MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanSearch for more papers by this authorTomohiro Miki MD, Tomohiro Miki MD Department of Internal Medicine I, Osaka Teishin Hospital, Osaka, JapanSearch for more papers by this authorShodayu Takashima MD, Shodayu Takashima MD Department of Radiology, Osaka Teishin Hospital, Osaka, JapanSearch for more papers by this authorJun-Ichi Yoshida MD, Jun-Ichi Yoshida MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanSearch for more papers by this author Arata Horii MD, Corresponding Author Arata Horii MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanDepartment of Otolaryngology, Osaka University MEdical School, 2-2 Yamadaoka, Suita, Osaka 565, JapanSearch for more papers by this authorKazuo Shimamura MD, Kazuo Shimamura MD Department of Pathology, Tokai University School of Medicine, Kanagawa, JapanSearch for more papers by this authorYuichiro Honjo MD, Yuichiro Honjo MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanSearch for more papers by this authorKenji Mitani MD, Kenji Mitani MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanSearch for more papers by this authorTomohiro Miki MD, Tomohiro Miki MD Department of Internal Medicine I, Osaka Teishin Hospital, Osaka, JapanSearch for more papers by this authorShodayu Takashima MD, Shodayu Takashima MD Department of Radiology, Osaka Teishin Hospital, Osaka, JapanSearch for more papers by this authorJun-Ichi Yoshida MD, Jun-Ichi Yoshida MD Department of Otolaryngology, Head and Neck Surgery, Osaka Teishin Hospital, Osaka 543, JapanSearch for more papers by this author First published: 07 December 1998 https://doi.org/10.1002/(SICI)1097-0347(199707)19:4 3.0.CO;2-CCitations: 19AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Background Leukocytosis without infection in patients with malignancies is known as the leukemoid reaction. The mechanisms involved in this phenomenon remain uncertain. Methods We describe the clinical, biochemical and immunohistochemical findings in a patient with recurrent tongue carcinoma accompanied by marked leukocytosis as high as 96200/mm3. Results The serum granulocyte colony stimulating factor (G-CSF) concentration was increased to 204 (normal: < 30) pg/ml, which paralleled to the elevation of white blood cell (WBC) count and the tumor growth. The G-CSF content of the tumor tissue was also elevated (131 pg/mg protein) compared to that in control patients (6.63±2.63 pg/mg protein). Production of G-CSF from the tumor was evidenced by immunohistochemical staining with monoclonal antibody against human recombinant G-CSF. Conclusions We suggest that the G-CSF production of the tumor participates in the mechanisms of the leukemoid reaction. © 1997 John Wiley & Sons, Inc. Head Neck 19: 251–356, 1997. Citing Literature Volume19, Issue4July 1997Pages 351-356 RelatedInformation