Endocrine Consequences of Hypophysectomy
1963; Lippincott Williams & Wilkins; Volume: 24; Issue: 4 Linguagem: Inglês
10.1097/00000542-196307000-00016
ISSN1528-1175
Autores Tópico(s)Adrenal and Paraganglionic Tumors
ResumoTOTAL hypophysectomy in man has become a practical therapeutic procedure for the man-agement of certain endocrine disorders,1 meta-static cancer,2 and vascular changes associated with diabetes mellitus.3 The successful ac-complishment of this ablative procedure was dependent upon the availability of target organ hormones for replacement, namely cortisone, thyroid and gonadal steroids. Surgical re-moval of the pituitary by way of a transfrontal craniotomy has proved to be a satisfactory means of accomplishing total hypophysectomy with minimal morbidity and mortality.2 Other surgical approaches, namely, transantral-trans-phenoidal, transnasal-transphenoidal, and trans-ethmoid-transphenoidal have also been suc-cessfully employed. Yttrium-90 implantation of the pituitary with the use of trocars provides a much simpler approach which can apparently accomplish a nearly complete destruction of the gland with minimal risk of side effects.4 It is the purpose of this paper to review the endocrine consequences of hyphophysectomy and to discuss the management of these pa-tients during and after the procedure.
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