Revisão Revisado por pares

Endothelins as regulators of growth and function in endocrine tissues

1993; Wiley; Volume: 39; Issue: 3 Linguagem: Inglês

10.1111/j.1365-2265.1993.tb02363.x

ISSN

1365-2265

Autores

R.L. Kennedy, William G. Haynes, David J. Webb,

Tópico(s)

Hormonal Regulation and Hypertension

Resumo

Clinical EndocrinologyVolume 39, Issue 3 p. 259-265 Endothelins as regulators of growth and function in endocrine tissues R. L. Kennedy, Corresponding Author R. L. Kennedy Department of Medicine, The University of Edinburgh, UKDr R. L. Kennedy, Department of Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Fax: 031 315 2436.Search for more papers by this authorW. G. Haynes, W. G. Haynes Department of Medicine, The University of Edinburgh, UKSearch for more papers by this authorD. J. Webb, D. J. Webb Department of Medicine, The University of Edinburgh, UKSearch for more papers by this author R. L. Kennedy, Corresponding Author R. L. Kennedy Department of Medicine, The University of Edinburgh, UKDr R. L. Kennedy, Department of Medicine, The University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK. Fax: 031 315 2436.Search for more papers by this authorW. G. Haynes, W. G. Haynes Department of Medicine, The University of Edinburgh, UKSearch for more papers by this authorD. J. Webb, D. J. Webb Department of Medicine, The University of Edinburgh, UKSearch for more papers by this author First published: September 1993 https://doi.org/10.1111/j.1365-2265.1993.tb02363.xCitations: 30AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Alam, A.S.M.T., Gallacher, A., Shankar, V., Ghatei, M.A., Datta, H.K., Huang, C.L-H., Moonga, B.S., Chambers, T.J., Bloom S.R. & Zaidi, M. (1992) Endothelin inhibits osteoclastic bone resorption by a direct effect on cell motility: implications for the vascular control of bone resorption. Endocrinology, 130, 1617– 1624. Arai, H., Hori, S., Aramori, I., Ohkubo, H. & Nakanishi, S. (1990) Cloning and expression of a cDNA encoding an endothelin receptor. Nature, 348, 730– 732. Arnaout, M.A., Awidi, A.S., El Najdawi, A.M., Khateeb, M.S. & Ajlouni, K.M. (1992) Arginine vasopressin and endothelin associated proteins in thyroid disease. Acta Endocrinological 126, 399– 403. Benigni, A., Gaspari, F., Orisio, S., Bellizzi, L., Amuso, G., Frusca, T., Remuzzi, G. (1991) Human placenta expresses endothelin gene and corresponding protein is excreted in urine in increasing amounts during normal pregnancy. American Journal of Obstetrics and Gynecology, 164, 844– 848. Bigaud, M. & Pelton, J.J. (1992) Discrimination between ETA- and ETB-receptor-mediated effects of endothelin-1 and [Ala1,3,11,15]-endothelin-1 by BQ-123 in the anaesthetized rat. British Journal of Pharmacology, 107, 912– 918. Boarder, M.R. & Marriott, D.B. (1989) Characterization of endoth-elin-1 stimulation of catecholamine release from adrenal chromaffin cells. Journal of Cardiovascular Pharmacology, 13, S223– S224. Branch, D.W., Dudley, D.J. & Mitchell, M.D. (1991) Preliminary evidence for homeostatic mechanism regulating endothelin production in pre-eclampsia. Lancet, 337, 943– 945. Brown, M.A., Zammit, V.C., Whitworth, J.A., Magoulas, T. & Penny, R. (1991) Endothelin production in pre-eclampsia. Lancet, 338, 943. Burris, T.B., Kanyicska, B. & Freeman, M.E. (1991) Inhibition of prolactin secretion by endothelin-3 is pertussis toxin-sensitive. European Journal of Pharmacology, 198, 223– 225. Casey, M.L. (1992) Massive amounts of endothelin in murine seminal fluid. Journal of Clinical Endocrinology and Metabolism, 74, 223– 225. Colin, I., Berbinschi, A., Denef, J.F. & Ketelslegers, J.M. (1992) Detection and identification of endothelin-1 immunoreactivity in rat and porcine thyroid follicular cells. Endocrinology, 130, 544– 546. Cozza, E.N., Gomez-Sanchez, C.E., Foecking, M.F. & Chiou, S. (1989) Endothelin binding to cultured calf adrenal glomerulosa cells and stimulation of aldosterone secretion. Journal of Clinical Investigation, 84, 1032– 1035. De Feo, ML., Bartolini, O., Orlando, C, Maggi, M., Serio, M., Pines, M., Hurwitz, S., Fujii, Y., Sakaguchi, K., Aurbach, G.D. & Brandi, M.L. (1991) Natriuretic peptide receptors regulate endothelin synthesis and release from parathyroid cells. Proceedings of the National Academy of Sciences, USA, 88, 6496– 6500. Domae, M., Yamada, K., Hanabusa, Y. & Furukawa, T. (1992) Inhibitory effects of endothelin-1 and endothelin-3 on prolactin release: possible involvement of endogenous endothelin isopep-tides in the rat anterior pituitary. Life Sciences, 50, 715– 722. Douglas, S.A. & Hiley, C.R. (1990) Endothelium-dependent vascular activities of endothelin-like peptides in the isolated superior mesenteric arterial bed of the rat. British Journal of Pharmacology, 101, 81– 88. Ergul, A., Glassberg, M.K., Majercik, M.H. & Puett, D. (1993) Endothelin-1 promotes steroidogenesis and stimulates protooncogene expression in transformed murine leydig cells. Endocrinology, 132, 598– 603. Ericson, L.E. & Wollman, S.H. (1980) Increase in the rough endoplasmic reticulum in capillary endothelial cells and pericytes in hyperplastic rat thyroid glands. Endocrinology, 107, 732– 737. Fujii, Y., Moreira, J.E., Orlando, C, Maggi, M., Aurbach, G., Brandi, M.L. & Sakaguchi, K. (1991) Endothelin as an autocrine factor in the regulation of parathyroid cells. Proceedings of the National Academy of Sciences, USA, 88, 4235– 4239. Fukuda, Y., Hirata, Y., Taketani, S., Takatsugu, K., Oikawa, S., Nakazato, H. & Kobayashi, Y. (1989) Endothelin stimulates accumulation of atrial natriuretic peptide and its messenger RNA in rat cardiocytes. Biochemical and Biophysical Research Communications, 164, 1431– 1436. Garcia, R., Lachance, D. & Thibault, G. (1990) Positive inotropic action, natriuresis and atrial natriuretic factor release induced by endothelin in the conscious rat. Journal of Hypertension, 8, 725– 731. Goetz, K.L., Wang, B.C., Madwed, J.B., Zuh, J.L. & Lendley, R.J. (1988) Cardiovascular, renal and endocrine responses to intravenous endothelin in conscious dogs. American Journal of Physiology, 255, R1064– 1068. Harrison, V.J., Randriantsoa, A. & Schoeffter, P. (1992) Heterogeneity of endothelin-sarafatoxin receptors mediating contraction of pig coronary artery. British Journal of Pharmacology, 105, 511– 513. Haynes, W.G. & Webb, D.J. (1993) The endothelin family of peptides: local hormones with diverse roles in health and disease. Clinical Science, 84, 485– 500. Hinson, J.P., Kapas, S., Teja, R. & Vinson, G.P. (1991a) Effect of endothelins on aldosterone secretion by rat zona glomerulosa cells in vitro. Journal of Steroid Chemistry and Molecular Biology, 40, 437– 439. Hinson, J.P., Vinson, G.P., Kapas, S. & Teja, R. (1991b) The relationship between adrenal vascular events and steroid secretion: the role of mast cells and endothelin. Journal of Steroid Chemistry and Molecular Biology, 40, 381– 389. Hinson, J.P., Vinson, G.P., Kapas, S. & Teja, R. (1991c) The role of endothelin in the control of adrenocortical function: stimulation of endothelin release by ACTH and the effects of endothelin-1 and endothelin-3 on steroidogenesis in rat and human adrenocortical cells. Journal of Endocrinology, 128, 275– 280. Hughes, A.K., Chne, R.C. & Kohan, D.E. (1992) Alterations in renal endothelin-1 production in the spontaneously hypertensive rat. Hypertension, 20, 666– 673. Inoue, A., Yanagisawa, M., Kimura, S., Kasuya, Y., Miyauchi, T., Goto, K. & Masaki, T. (1989) The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proceedings of the National Academy of Sciences, USA, 86, 286– 287. Iwai, M., Hasegawa, M., Taii, S., Sagawa, N., Nakao, K., Imura, H., Nakanashi, S. & Mori, T. (1991) Endothelins inhibit luteinization of cultured porcine granulosa cells. Endocrinology, 129, 1909– 1914. Jackson, S., Tseng, Y-C, Lahiri, S., Burman, K.D. & Wartofsky, L. (1992) Receptors for endothelin in cultured human thyroid cells and inhibition by endothelin of thyroglobulin secretion. Journal of Clinical Endocrinology and Metabolism, 75, 388– 392. Kamada, S., Kubota, T., Hirata, Y., Taguchi, M., Eguchi, S., Marumo, F. & Aso, T. (1992) Direct effect of endothelin-1 on the granulosa cells of the porcine ovary. Journal of Endocrinology, 134, 59– 66. Kamoi, K., Sudo, N., Ishibashi, M. & Yamaji, T. (1990) Plasma endothelin levels in patients with pregnancy-induced hypertension. New England Journal of Medicine, 323, 1486– 1487. Kanyicska, B., Burris, T.B. & Freeman, M.E. (1991a) Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture. Biochemical and Biophysical Research Communications, 174, 338– 343. Kanyicska, B., Burris, T.B. & Freeman, M.E. (1991b) The effects of endothelins on the secretion of prolactin, luteinizing hormone and follicle-stimulating hormone are mediated by different guanine nucleotide-binding proteins. Endocrinology, 129, 2607– 2613. Kaufmann, H., Oribe, E. & Oliver, J.A. (1991) Plasma endothelin during upright tilt: relevance for orthostatic hypotension. Lancet, 388, 1542– 1545. Kawaguchi, H., Sawa, H. & Yasuda, H. (1991) Effect of endothelin on angiotensin converting enzyme in cultured pulmonary artery endothelial cells. Journal of Hypertension, 9, 171– 174. Kohan, D.E. (1991) Endothelin synthesis by rabbit renal tubule cells. American Journal of Physiology, 261, F221– F226. Kohan, D.E., Hughes, A.K. & Perkins, S.L. (1992) Characterisation of endothelin receptors in the inner medullary collecting duct of the rat. Journal of Biological Chemistry, 267, 12336– 12340. Kohan, D.E. & Padilla, E. (1993)Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct. Journal of Clinical Investigation, 91, 1235– 1240. Kohno, M., Yasunari, K., Yokokawa, K., Murakawa, K., Horio, T. & Takeda, T. (1991) Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. Journal of Clinical Investigation, 87, 1999– 2004. Lopez-Farre, A., Montanes, I., Millus, I. & Lopez-Nova, J.M. (1989) Effect of endothelin on renal function in rats. European Journal of Pharmacology, 163, 187– 189. Makino, S., Hashimoto, K., Hirasawa, R., Hattori, T. & Ota, Z. (1992). Central interaction between endothelin and brain natriuretic peptide on vasopressin secretion. Journal of Hypertension, 10, 25– 28. Many, M-C, Denef, J.F. & Haumont, S. (1984) Precocity of endothelial proliferation during the course of rapid goitrogenesis. Acta Endocrinologica, 105, 487– 491. Martin, E.R., Brenner, B.M. & Ballerman, B.J. (1990) Heterogeneity of cell surface endothelin receptors. Journal of Biological Chemistry, 265, 14044– 14049. Matsumoto, H., Suzuki, N., Onda, H. & Fujino, M. (1989) Abundance of endothelin-3 in rat intestine, pituitary gland and brain. Biochemical and Biophysical Research Communications, 164, 74– 80. Matsumoto, H., Suzuki, N., Shiota, T., Inoue, K., Tsuda, M. & Fujino, M. (1990) Insulin-like growth factor-1 stimulates endothelin- 1 secretion from rat anterior pituitary cells in primary culture. Biochemical and Biophysical Research Communications, 172, 661– 668. Matsumura, K., Abe, I., Tsuchihashi, T., Tominaga, M., Kobayashi, K. & Fujishama, M. (1991) Central effect of endothelin on neurohumoral responses in conscious rabbits. Hypertension, 17, 1192– 1196. Miller, W.L., Redfield, M.M. & Burnett, J.C. (1989) Integrated cardiac, renal and endocrine actions of endothelin. Journal of Clinical Investigation, 83, 317– 320. Miyazaki, A., Hanafusa, T., Itoh, N., Miyagawa, I., Kono, T., Tarui, S., Kiyotaki, C. & Yoshizaki, K. (1989) Demonstration of interleukin-1 beta on perifollicular endothelial cells in the thyroid glands of patients with Graves' disease. Journal of Clinical Endocrinology and Metabolism, 69, 738– 744. Moe, O., Tejedor, A., Campbell, W.B., Alpern, R.J. & Henrich, W.L. (1991) Effects of endothelin on in vitro renin secretion. American Journal of Physiology, 260, E521– E525. Mondon, F., Malassine, A., Robaut, C, Vial, M., Bandet, J., Tanguy, G., Rostene, W., Cavero, I. & Ferre, F. (1993) Biochemical characterization and autoradiographic localization of [125I]endothelin-l on trophoblast and blood vessels of human placenta. Journal of Clinical Endocrinology and Metabolism, 76, 237– 244. Moreland, S., McMullen, D.N., Dclaney, C. L, Lee, V.G. & Hunt, J.T. (1992) Venous smooth muscle contains vasoconstrictor ETB- like receptors. Biochemical and Biophysical Research Communications, 184, 100– 106. Moretto, M., Lopez, F.J. & Negro-Vilar, A. (1993) Endothelin-3 stimulates luteinizing hormone-releasing hormone (LHRH) secretion from LHRH neurons by a prostaglandin-dependent mechanism. Endocrinology 132, 789– 794. Nakamoto, H., Suzuki, H., Murakami, M., Ohishi, A., Fukuda, K., Hori, S. & Saruta, T. (1989) Effects of endothelin on systemic and renal haemodynamics and neuroendocrine hormones in conscious dogs. Clinical Science, 11, 567– 572. Oishi, R., Monoguchi, H., Tomita, K. & Murumo, F. (1991) Endothelin-1 inhibits AVP stimulated osmotic water permeability in rat inner medullary collecting duct. American Journal of Physiology, 261, F951– F956. O'Reilly, G.O., Charnock-Jones, D.S., Davenport, A.P., Cameron, I.T. & Smith, S.K. (1992) Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle. Journal of Clinical Endocrinology and Metabolism, 75, 1545– 1549. Orlando, C, Brandi, M.L., Peri, A., Giannini, S., Fantoni, G., Galabresi, E., Serio, M. & Maggi, M. (1990) Neurohypophyseal hormone regulation of endothelin secretion from rabbit endometrial cells in primary culture. Endocrinology, 126, 1780– 1782. Rakugi, H., Tabachi, Y., Nakamaru, M., Nagano, M., Higashimori, K., Mikami, H. & Ogihara, T. (1990) Endothelin activates the vascular renin-angiotensin system in rat mesenteric arteries. Biochemistry International, 21, 867– 872. Resink, T.J., Hahn, A.W., Scott-Burden, T., Powell, J., Weber, E. & Buhler, F.R. (1990) Inducible endothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells. Biochemical and Biophysical Research Communications, 168, 1303– 1310. Rosolowski, I.J. & Campbell, W.B. (1990) Endothelin enhances adrenocorticotropin-stimulated aldosterone release from cultured bovine adrenal cells. Endocrinology, 126, 1860– 1866. Saijonmaa, O., Ristimaki, A. & Fyrquist, F. (1990) Atrial natriuretic peptide, nitroglycerine, and nitroprusside reduce basal and stimulated endothelin production from cultured endothelial cells. Biochemical and Biophysical Research Communications, 173, 514– 520. Sakurai, T., Yanagisawa, M., Takuwa, Y., Miyazaki, H., Kimura, S., Goto, K. & Masaki, T. (1990) Cloning of cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature, 348, 732– 735. Samson, W.K. & Skala, K.D. (1992) Comparison of the pituitary effects of the mammalian endothelins: vasoactive intestinal contractor (endothelin-B, rat endothelin-2) is a potent inhibitor of prolactin secretion. Endocrinology, 130, 2964– 2970. Samson, W.K., Skala, K.D., Alexander, B.D. & Huang, F-L.S. (1990) Pituitary site of action of endothelin: selective inhibition of prolactin releas. in vitro. Biochemical and Biophysical Research Communications, 169, 737– 743. Samson, W.K., Skala, K.D., Alexander, B.D. & Huang, F-L.S. (1991a) Hypothalamic endothelin: presence and effects related to fluid and electrolyte homeostasis. Journal of Cardiovascular Pharmacology, 17, 346– 349. Samson, W.K., Skala, K.D., Alexander, B. & Huang, F-L.S. (1991b) Possible neuroendocrine actions of endothelin-3. Endocrinology, 128, 1465– 1473. Shichiri, M., Hirata, Y., Nakajima, T., Ando, K., Imai, T., Yanagisawa, M., Masaki, T. & Marumo, F. (1991) Endothelin-1 is an autocrine/paracrine growth factor for human cancer cell lines. Journal of Clinical Investigation, 87, 1867– 1871. Schiff, E., Ben-Baruch, G., Galron, R., Masiach, S. & Sokolovsky, M. (1993) Endothelin-1 receptors in the human myometrium: evidence for differential binding properties in post-menopausal as compared to premenopausal and pregnant women. Clinical Endocrinology, 38, 321– 324. Simonson, M.S. & Dunn, M.J. (1991) Endothelins: a family of regulatory peptides. Hypertension, 17, 856– 863. Stasch, J.P., Hirth-Dietrich, C, Kazda, S. & Neuser, D. (1989) Endothelin stimulates release of atrial natriuretic peptides in vitro an. in vivo. Life Sciences, 45, 869– 875. Stojilkovic, S.S., Iida, T., Merelli, F. & Catt, K.J. (1991) Calcium signalling and secretory responses in endothelin-stimulated anterior pituitary cells. Molecular Pharmacology, 39, 762– 770. Stojilkovic, S.S., Merelli, F., Iida, T., Krsmanovickz, C. & Catt, K.J. (1990) Endothelin stimulation of cytosolic calcium and gonadotropin secretion in anterior pituitary cells. Science, 248, 1663– 1666. Sumner, M.J., Cannon, T.R., Mundin, J.W., White, D.G. & Watts, I.S. (1992) Endothelin ETA and ETB receptors mediate vascular smooth muscle contraction. British Journal of Pharmacology, 107, 858– 860. Suzuki, E., Hirata, Y., Matsuoka, H., Sugimoto, T., Hayakawa, H., Shin, W.S., Toyooka, T. & Sugimoto, T. (1991) Effects of atrial natriuretic peptide on endothelin-induced vasoconstriction and intracellular calcium mobilization. Journal of Hypertension, 9, 927– 934. Takahashi, Y., Ghatei, M.A., Lam, H-C, O'Halloran, D.J. & Bloom, S.R. (1990) Elevated plasma endothelin in patients with diabetes mellitus. Diabetologia, 33, 306– 310. Takahashi, K., Ghatei, M.A., Jones, P.M., Murphy, J.K., Lam, H-C, O'Halloran, A.J. & Bloom, S.R. (1991a) Endothelin in human brain and pituitary gland: presence of immunoreactive endothelin, endothelin messenger ribonucleic acid and endothelin receptors. Journal of Clinical Endocrinology and Metabolism, 72, 643– 649. Takahashi, K., Suda, K., Lam, H-C, Ghatei, M.A. & Bloom, S.R. (1991b) Endothelin-like immunoreactivity in rat models of diabetes mellitus. Journal of Endocrinology, 130, 123– 127. Taylor, R.N., Varma, M., Teng, N.N.H. & Roberts, J.M. (1990) Women with pre-eclampsia have higher plasma endothelin levels than women with normal pregnancies. Journal of Clinical Endocrinology and Metabolism, 71, 1675– 1677. Tseng, Y-C, Lahiri, S., Jackson, S., Burman, K.D. & Wartofsky, L. (1993) Endothelin binding to receptors and endothelin production by human thyroid follicular cells: effects of transforming growth factor-β and thyrotropin. Journal of Clinical Endocrinology and Metabolism, 76, 156– 161. Tsunoda, K., Abe, K., Sato, T., Yokosawa, S. & Yoshinaga, K. (1991) Decreased conversion of big endothelin-I in patients with diabetes mellitus. Clinical and Experimental Pharmacology and Physiology, 18, 731– 732. Tsushima, T., Arai, M., Miyakawa, M., Isozaki, O., Shizume, K., Demura, H., Murakami, Y., Onoda, N. & Sato, Y. (1992) Effects of endothelin (ET) on growth and functions of thyroid cells in culture. Proceedings of the 9th International Congress of Endocrinology, Nice, France; August 30th-September 5th, 1992, Abstract 05.01.017. Usuki, S., Suzuki, N., Matsumoto, H., Yanagisawa, M. & Masaki, T. (1991) Endothelin-1 in luteal tissue. Molecular and Cellular Endocrinology, 80, 147– 151. Warner, T.D., de Nucci, G. & Vane, J.R. (1989) Rat endothelin is a vasodilator in the isolated perfused mesentery of the rat. European Journal of Pharmacology, 159, 325– 326. Wollman, S.H., Herveg, J.P., Zeligs, J. & Ericson, L.E. (1978) Blood capillary enlargement during the development of thyroid hyperplasia in the rat. Endocrinology, 103, 2308– 2314. Wong-Dusting, H.K., La, M. & Rand, M.J. (1990) Mechanisms of the effects of endothelin on responses to noradrenaline and sympathetic nerve stimulation. Clinical and Experimental Pharmacology and Physiology, 17, 269– 273. Word, R.A., Kamm, K.E., Stull, J.T. & Casey, M.L. (1990) Endothelin increases cytoplasmic calcium and myosin phosphorylation in myometrium. American Journal of Obstetrics and Gynecology, 162, 1103– 1108. Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Yazaki, Y., Goto, K. & Masaki, T. (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature, 332, 411– 415. Yokokawa, K., Tahara, H., Kohno, M., Murakawa, K., Yasunari, K., Nakagawa, K., Hamada, T., Otani, S., Yanagisawa, M. & Takeda, T. (1991) Hypertension associated with endothelin-secreting malignant hemangioendothelioma. Annals of Internal Medicine, 114, 213– 215. Yoshizawa, T., Shinmi, O., Graid, A., Yanagisawa, M., Gibson, S.J., Kimura, S., Uchiyama, Y., Polak, J.M., Masaki, T. & Kanazawa, I. (1990) Endothelin: a novel peptide in the posterior pituitary system. Science, 247, 462– 464. Yoshizumi, M., Kurihara, H., Morita, T., Yamashita, T., Oh-hashi, Y., Sugiyama, T., Takaku, F., Yanagisawa, M., Masaki, T. & Yazaki, Y. (1990) Interleukin-1 increases the production of endothelin-1 by cultured endothelial cells. Biochemical and Biophysical Research Communications, 166, 324– 329. Zeidel, M.L., Brady, H.R., Kone, B.C., Gullans, S.R. & Brenner, B.M. (1989) Endothelin, a peptide inhibitor of sodium Na+-K+-ATPase, in intact renal tubular endothelial cells. American Journal of Physiology, 257, C1101– C1107. Citing Literature Volume39, Issue3September 1993Pages 259-265 ReferencesRelatedInformation

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