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Mucositis and salivary antioxidants in patients undergoing bone marrow transplantation (BMT)

2014; Medicina Oral S.L.; Linguagem: Inglês

10.4317/medoral.19062

1698-6946

Eva Bachmeier, MA Mazzeo, M.E. Gas López, JA. Linares, Gustavo Jarchum, FM. Wietz, AB. Finkelberg,

Head and Neck Cancer Studies

O�jectives: Hi�� doses o� c�e�ot�erapy �enerate ��� da�a�e in patients under�oin� �one �arrow transplantation (BMT)� due to t�e production o� reactive oxy�en species (ROS).In order to evaluate t�e local de�ensive e��ectiveness o� t�e patient under�oin� BMT� t�e concentrations o� t�e antioxidants superoxide dis�utase (SO�) and uric acid (U�) were �easured in saliva.Study �esi�n: Basal saliva sa�ples were collected �ro� 20 patients under�oin� BMT at t�e Oncolo�y �epart-�ent� Sanatorio �llende (C�rdo�a)� in t�e sta�es: initial� prior to conditionin� t�erapy (I); �iddle: 7 to 10 days after BMT (M) and final stage, 30 days after discharge from isolation (F).SOD levels were determined using a R���OX kit (R��SO� superoxide dis�utase �anual)� and �or uric acid enzy�atic UO� / P�P spectrop�oto-�etric �et�od� ( Trinder Color Kit � Wiener La�) was used.Results: 85% of the patients developed oral mucositis.SOD concentration in the M stage was significantly higher (p<0.01)compared with stage I, and it reversed in stage F. UA concentration was significantly lower (p<0.001) in sta�e M co�pared wit� sta�e I� and in sta�e � it recovered t�e initial values.Conclusions: SO� increase in sta�e M coincided wit� t�e appearance o� �ucositis� w�ic� could �e interpreted as a de�ensive �ec�anis� o� saliva a�ainst oxidative stress produced �y c�e�ot�erapy.U� decrease in sta�e M would �avour t�e develop�ent o� �i��er de�rees o� �ucositis.