C-fibres provide a source of masking inhibition to primary somatosensory cortex
1991; Royal Society; Volume: 243; Issue: 1308 Linguagem: Inglês
10.1098/rspb.1991.0041
ISSN1471-2954
Autores Tópico(s)Neuroscience and Neural Engineering
ResumoRestricted accessMoreSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail Cite this article Calford Mike B. and Tweedale Rowan 1991C-fibres provide a source of masking inhibition to primary somatosensory cortexProc. R. Soc. Lond. B.243269–275http://doi.org/10.1098/rspb.1991.0041SectionRestricted accessArticleC-fibres provide a source of masking inhibition to primary somatosensory cortex Mike B. Calford Google Scholar Find this author on PubMed Search for more papers by this author and Rowan Tweedale Google Scholar Find this author on PubMed Search for more papers by this author Mike B. Calford Google Scholar Find this author on PubMed and Rowan Tweedale Google Scholar Find this author on PubMed Published:22 March 1991https://doi.org/10.1098/rspb.1991.0041AbstractCapsaicin was applied to the exposed radial nerve of adult flying foxes (n = 5) and cats (n = 2) while recording in primary somatosensory cortex from a single neuron with a receptive field on digits 1 or 2. Within four minutes of application of capsaicin the borders of these receptive fields dramatically expanded. In a further four flying foxes it was shown, with subcutaneous delivery just proximal to the receptive fields, that capsaicin need affect only afferents from the region of a neuron's receptive field to induce expansion. Capsaicin applied directly to a nerve, or subcutaneously in high concentrations, is a selective neurotoxin that rapidly prevents the propagation of action potentials in most C-fibres. The result provides a partial explanation for experiments involving the specific and complete denervation of receptive fields of neurons in primary somatosensory cortex. Such denervation does not lead to unresponsiveness but to immediate sensitivity to stimulation of areas surrounding the original fields. Thus it appears that some subclass of capsaicin-sensitive C-fibres provides a primary source for the masking inhibition that normally limits the extent of the receptive fields of cortical neurons.FootnotesThis text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR. 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