Phosphate homeostasis and disorders
2014; SAGE Publishing; Volume: 51; Issue: 6 Linguagem: Inglês
10.1177/0004563214521399
ISSN1758-1001
AutoresP. Manghat, Ravinder Sodi, R. Swaminathan,
Tópico(s)Biomedical Research and Pathophysiology
ResumoRecent studies of inherited disorders of phosphate metabolism have shed new light on the understanding of phosphate metabolism. Phosphate has important functions in the body and several mechanisms have evolved to regulate phosphate balance including vitamin D, parathyroid hormone and phosphatonins such as fibroblast growth factor-23 (FGF23). Disorders of phosphate homeostasis leading to hypo- and hyperphosphataemia are common and have clinical and biochemical consequences. Notably, recent studies have linked hyperphosphataemia with an increased risk of cardiovascular disease. This review outlines the recent advances in the understanding of phosphate homeostasis and describes the causes, investigation and management of hypo- and hyperphosphataemia.
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