Revisão Acesso aberto Revisado por pares

Phosphate homeostasis and disorders

2014; SAGE Publishing; Volume: 51; Issue: 6 Linguagem: Inglês

10.1177/0004563214521399

ISSN

1758-1001

Autores

P. Manghat, Ravinder Sodi, R. Swaminathan,

Tópico(s)

Biomedical Research and Pathophysiology

Resumo

Recent studies of inherited disorders of phosphate metabolism have shed new light on the understanding of phosphate metabolism. Phosphate has important functions in the body and several mechanisms have evolved to regulate phosphate balance including vitamin D, parathyroid hormone and phosphatonins such as fibroblast growth factor-23 (FGF23). Disorders of phosphate homeostasis leading to hypo- and hyperphosphataemia are common and have clinical and biochemical consequences. Notably, recent studies have linked hyperphosphataemia with an increased risk of cardiovascular disease. This review outlines the recent advances in the understanding of phosphate homeostasis and describes the causes, investigation and management of hypo- and hyperphosphataemia.

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