Cutaneous toxicities of RAF inhibitors
2012; Elsevier BV; Volume: 14; Issue: 1 Linguagem: Inglês
10.1016/s1470-2045(12)70413-8
ISSN1474-5488
AutoresRachael Anforth, Pablo Fernández‐Peñas, Georgina V. Long,
Tópico(s)PI3K/AKT/mTOR signaling in cancer
ResumoThe RAF inhibitors vemurafenib and dabrafenib are emerging as the standard of care for Val600 BRAF-mutant metastatic melanoma. These drugs have shown clinical benefit over the standard care (dacarbazine); however, they are associated with frequent cutaneous adverse events, which can be concerning to the patient and their physician. Herein, we review the range of cutaneous disorders that seem to be induced by RAF inhibitors, including cutaneous squamous-cell carcinoma, hyperkeratotic lesions, Grover's disease, keratosis pilaris-like reactions, and photosensitivity. These disorders often affect patients' quality of life; therefore, dermatological assessment and timely management is essential to ensure that patients continue to use RAF inhibitors.
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