Antiplasmodial and Prehemolytic Activities of α‐Peptide–β‐Peptoid Chimeras
2007; Wiley; Volume: 8; Issue: 15 Linguagem: Inglês
10.1002/cbic.200700385
ISSN1439-7633
AutoresLine Vedel, Gitte Bonke, Camilla Foged, Hanne L. Ziegler, Henrik Franzyk, Jerzy W. Jaroszewski, Christian A. Olsen,
Tópico(s)Carbohydrate Chemistry and Synthesis
ResumoKilling them softly. The in vitro elimination of malaria parasites with biomimetic oligomers is described. Antiplasmodial activity and varying hemolytic and prehemolytic effects were observed with a α-peptide–β-peptoid chimera that selectively perturbed Plasmodium falciparum-infected red blood cells (IC50 21 μm; see figure). The fact that structural variations can result in different profiles of antiplasmodial versus hemolytic/prehemolytic effects opens new possibilities in peptidomimetic research.
Referência(s)