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A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

2008; Royal Society of Chemistry; Volume: 4; Issue: 6 Linguagem: Inglês

10.1039/b719423d

1742-206X

Irene Kiburu, Andrew Shurer, Lei Yan, Herman O. Sintim,

RNA and protein synthesis mechanisms

Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.