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The Use of Forane Anesthesia for Surface-Induced Deep Hypothermia

1975; Elsevier BV; Volume: 20; Issue: 3 Linguagem: Inglês

10.1016/s0003-4975(10)64222-1

1552-6259

Shigekazu Sato, Vittorio Vanini, Murray P. Sands, K. C. Wong, Hitoshi Mohri, K. Alvin Merendino,

Cardiac Arrest and Resuscitation

The effects of Forane anesthesia for deep surface hypothermia with 30 minutes of total circulatory occlusion were evaluated.With 100%02 6 of 7 dogs developed motor disorders postoperatively, while 3 of 5 with 98% OJ2% COz and none with 95% 02/5% COz developed motor disorders.Cooling was uneventful except for 1 episode of ventricular fibrillation in the 5% COz group at 23°C.Resuscitation was easy, but the early rewarming period was characterized by repeated episodes of ventricular fibrillation and delayed recovery of cardiac function, especially in the 100% 0, group.Blood lactate levels remained low during cooling and gradually increased during rewarming in all groups, with the highest levels in the 100% 0, group and the lowest in the 5% C02 group.It is concluded that Forane can be used for surface hypothermia with 30 minutes' circulatory occlusion when administered in 95% OJ5% C02.A comparison of these results with previously reported series indicates that Forane is inferior to ether but may be superior to halothane for surface hypothermia.orrection of congenital heart disease in early infancy has gained popularity in recent years, and the concept of attempting early C repair has been considered successful 11, 2, 4, 7,11,16,20, 221.Many surgeons use surface hypothermia with total circulatory arrest [2,6-8,11,15,16, 221, while others [l, 4, 51 prefer extracorporeal circulation.At this institution, early correction of congenital heart disease has been carried out utilizing surface hypothermia since 1965 [6-8, 151.Based on our experimental results, we prefer ether to other anesthetic agents in our clinical protocol, while halothane is the agent of choice in many other institutions [2, 16, 221.Our experimental studies have demonstrated the superiority of ether anesthesia to halothane anesthesia for hypothermic applications [ 14,18,19].However, the explosive characteristics, slow induction, and slow recovery associated with ether are considered to be shortcomings of this agent.