Place cells in the hippocampus: Eleven maps for eleven rooms
2014; National Academy of Sciences; Volume: 111; Issue: 52 Linguagem: Inglês
10.1073/pnas.1421056111
ISSN1091-6490
AutoresC.B. Alme, Chenglin Miao, Karel Ježek, Alessandro Treves, Edvard I Moser, May‐Britt Moser,
Tópico(s)Neuroinflammation and Neurodegeneration Mechanisms
ResumoSignificance The hippocampus is thought to store a large number of experiences that, despite their similarity, can be individually retrieved with minimal interference. Studies have shown that place cells in hippocampal area CA3 form statistically independent representations of pairs of environments. It has remained unclear, however, whether CA3 place cells maintain this independence when the number of environments is increased. We recorded activity from CA3 in 11 environments with nearly identical geometric features. Spatial firing patterns remained uncorrelated across all 55 pairs of environments, with minimal overlap in the populations of active cells. The data suggest that the capacity of the CA3 network is large and speak against extensive recurrence of spatial motifs across experiences.
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