Portal de Periódicos da CAPES

Cloning and Characterization of a Human and Murine T-Cell Orphan G-Protein-Coupled Receptor Similar to the Growth Hormone Secretagogue and Neurotensin Receptors

1998; Elsevier BV; Volume: 52; Issue: 2 Linguagem: Inglês

10.1006/geno.1998.5441

1089-8646

Carina P. Tan, Karen K. McKee, Qingyun Liu, Oksana Palyha, Scott D. Feighner, Donna L. Hreniuk, R G Smith, Andrew Howard,

Regulation of Appetite and Obesity

Growth hormone secretagogues (GHS) are a group of synthetic peptide and nonpeptide molecules that potently stimulate the release of GH from the anterior pituitary gland through the activation of a novel G-protein-coupled receptor (GPC-R), the GHS-R. In our search for GHS-R family members, we recently described the cloning of two related GPC-Rs, GPR38 and 39. In the present report, we detail the isolation of a new GPC-R (FM-3) from human and mouse with moderate sequence identity to both the GHS-R and neurotensin-R. FM-3 is expressed in a diverse set of tissues.