Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships
2008; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês
10.1016/j.bmcl.2008.11.090
ISSN1464-3405
AutoresTakao Horiuchi, Jun Chiba, Kouichi Uoto, Tsunehiko Soga,
Tópico(s)Synthesis and Reactivity of Heterocycles
ResumoThe synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.
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