Electrophoretic similarity of the ciliary ganglion survival factors from different tissues and species
1985; Elsevier BV; Volume: 109; Issue: 1 Linguagem: Inglês
10.1016/0012-1606(85)90367-7
ISSN1095-564X
Autores Tópico(s)Endoplasmic Reticulum Stress and Disease
ResumoThe survival of dissociated ciliary ganglion neurons is promoted by extracts of several different embryonic and adult tissues from two species. The survival-promoting activity in each of these extracts survives exposure to sodium dodecyl sulfate (SDS) and sulfhydryl-reducing agent and can, therefore, be subjected to SDS-polyacrylamide gel electrophoresis. Upon electrophoresis, the survival-promoting activity is recovered in a discrete peak at an apparent molecular weight of approximately 21,800 for all of the tissues examined. These results suggest that a similar molecule in each of these different tissues and species may be responsible for their ability to promote the survival of ciliary ganglion nerve cells in culture.
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