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Artigo Revisado por pares
BIBTEX RIS

Non thiazolidinedione antihyperglycaemic agents. 2: α-Carbon substituted β-phenylpropanoic acids1

1996; Elsevier BV; Volume: 6; Issue: 17 Linguagem: Inglês

10.1016/0960-894x(96)00382-4

ISSN

1464-3405

Autores

Derek R. Buckle, Barrie C. C. Cantello, Michael A. Cawthorne, Paul J. Coyle, David K. Dean, Andrew Faller, David Haigh, Richard M. Hindley, L. J. JEFCOTT, Carolyn A. Lister, Ivan L. Pinto, Harshad K. Rami, David G. Smith, Stephen A. Smith,

Tópico(s)

Lipid metabolism and biosynthesis

Resumo

The thiazolidine-2,4-dione ring of insulin sensitising antidiabetic agents can be replaced by α-acyl-, α-alkyl- and α-(aralkyl)-carboxylic acids. Inclusion of an additional lipophilic moiety affords compounds 14 and 16, equipotent to BRL 48482.

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