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Hemoglobin's moving around (to the tune of “Santa Claus is Coming to Town”)

2007; Wiley; Volume: 35; Issue: 6 Linguagem: Inglês

10.1002/bmb.118

1539-3429

Kevin Ahern,

Oh isn't it great What proteins can do Especially ones that bind to O2 Hemoglobin's moving around Inside of the lungs It picks up the bait And changes itself from T to R state Hemoglobin's moving around The proto-porphyrin system Its iron makes such a scene Arising when an O2 binds Pulling up on histidine The binding occurs Cooperatively Thanks to changes qua-ter-nar-y Hemoglobin's moving around It exits the lungs Engorged with O2 In search of a working body tissue Hemoglobin's moving around The proton concentration Is high and has a role Between the alpha betas It finds imidazole To empty their loads The globins decree “We need to bind 2,3BPG” Hemoglobin's moving around The stage is thus set For grabbing a few Cellular dumps of CO2 Hemoglobin's moving around And then inside the lungs it Discovers ox-y-gen And dumps the CO2 off To start all o'er again So see how this works You better expect To have to describe the Bohr effect Hemoglobin's moving around The on-line version of this article (available at http://www.bambed.org ) contains supplemental material, an MP3 performance of this song. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.