Portal de Periódicos da CAPES

Familial Aggregation of Insulin Resistance and Cardiovascular Risk Factors in Hypertension

2006; Wiley; Volume: 8; Issue: 11 Linguagem: Inglês

10.1111/j.1524-6175.2006.05761.x

1751-7176

Annaswamy Raji, Jonathan S. Williams, Paul N. Hopkins, Donald C. Simonson, Gordon H. Williams,

Birth, Development, and Health

The authors assessed the familial aggregation of cardiometabolic abnormalities (elevated homeostasis model assessment [HOMA], triglycerides [TG], and low-density lipoprotein [LDL] and reduced high-density lipoprotein [HDL]) among hypertensive siblings (N=287 from 138 families). Evidence for familial aggregation required sibling-pair concordance of outcome variables dichotomized according to predefined values (concordance for highest-quartile HOMA [>3.3], TG [>170 mg/dL], and LDL [>138 mg/dL] and lowest-quartile HOMA for HDL [<32 mg/dL]). Hypertensive individuals with insulin resistance (high-quartile HOMA) had higher TG and lower HDL and LDL levels compared with insulin-sensitive hypertensives. High-quartile HOMA, TG, and LDL aggregated in hypertensive families, and TG plus HOMA coaggregated. HDL did not show aggregation. In a multivariate logistic regression, the only significant predictor of an individual's HOMA status was a sibling's HOMA status in a model including age, sex, race, and body mass index (odds ratio=9.12; 95% confidence interval, 3.64-23.14; P<.001). Cardiometabolic variables demonstrate heritability in hypertensive families. Further exploration of common genetic susceptibility loci in hypertension involving these factors is warranted.