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Treatment of radiation‐induced dermatitis with light‐emitting diode (LED) photomodulation

2007; Wiley; Volume: 39; Issue: 2 Linguagem: Inglês

10.1002/lsm.20455

1096-9101

M. Maitland DeLand, Robert A. Weiss, David H. McDaniel, Roy G. Geronemus,

Tattoo and Body Piercing Complications

Abstract Background and Objective Light‐emitting diode (LED) photomodulation increases dermal collagen and reduces inflammation. This study evaluated the use of LED photomodulation in the prevention of radiation‐induced dermatitis in breast cancer. Materials and Methods Patients ( n = 19) were treated with LED photomodulation (Gentlewaves™, Light BioScience, LLC, Virginia Beach, VA) after each of a series of intensity‐modulated radiation treatments (IMRT). Skin reactions were monitored weekly with National Cancer Institute (NCI) criteria. Age‐matched controls ( n = 28) received IMRT without LED photomodulation. Results In LED‐treated patients, 18 (94.7%) had grade 0 or 1 reaction and 1 (5.3%) had grade 2 reaction. Among controls, 4 (14.3%) had a grade 1 reaction, 24 (85.7%) had a grade 2 or 3 reaction. One LED‐treated patient (5.3%) and 19 controls (67.9%) had to interrupt treatment. Conclusion LED photomodulation treatments immediately after IMRT reduces the incidence of NCI grades 1, 2, and 3 skin reactions in patients with breast cancer treated by radiation therapy (RT) postlumpectomy. Lasers Surg. Med. 39:164–168, 2007. © 2007 Wiley‐Liss, Inc.