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Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats.

1991; Japanese Pharmacological Society; Volume: 56; Issue: 4 Linguagem: Inglês

10.1254/jjp.56.547

1347-3506

Shoji Takakura, Teruo Susumu, Hisashi Satoh, Jo Mori, Akihiko Shiino, Jyoji Handa,

Sphingolipid Metabolism and Signaling

The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats. The area of infarction was measured 24 hr after occlusion of the middle cerebral artery (MCA) in spontaneously hypertensive rats using triphenyltetrazolium chloride. Nilvadipine, given immediately after MCA occlusion, reduced the area of infarction significantly at doses of 0.32 mg/kg (i.p.) and 3.2, 10 and 32 mg/kg (p.o.). Nicardipine suppressed the area of infarction at a dose of 32 mg/kg (p.o.). The results suggest that nilvadipine is effective against ischemic brain injury.