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The Distribution of HIV‐1 Subtypes in Fukuoka, Japan

1999; Wiley; Volume: 43; Issue: 3 Linguagem: Inglês

10.1111/j.1348-0421.1999.tb02403.x

1348-0421

Katsumi Chijiwa, Tetsuya Ishibashi, Seizaburo Kashiwagi, Ryoichi Mori,

HIV/AIDS drug development and treatment

Abstract To determine the incidence of human immunodeficiency virus type‐1 (HIV‐1) subtypes in Fukuoka, Japan, viruses from 41 HIV‐1 infected individuals were subtyped. Subtyping by V3‐loop enzyme‐linked immunosorbent assay (ELISA) showed 31 of the 41 subjects as subtype B (MN type), one as subtype A, one as subtype C, and eight untypable. The subject infected with subtype C was identified as a foreigner; the subtype A subject was Japanese. A phylogenetic analysis of nucleic acid sequences from the env C2‐V3 region was also conducted. Genetic subtyping was successful for 25 samples: 23 samples were determined as subtype B, one subtype A and one subtype E. One of the individuals infected with subtype B, as well as the subtype A and subtype E subjects, were not Japanese. This study indicated that subtype B (USA and European type) is still dominant among HIV‐1 infections in Fukuoka. Further, no Japanese were subtype E positive, which is increasing in the Kanto region. It is notable, however, that subtype A and subtype C infections, which are rare in Japan, were found in Fukuoka, located far from the metropolitan area of Tokyo.