Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions
2009; Royal Society of Chemistry; Issue: 12 Linguagem: Inglês
10.1039/b821317h
ISSN1364-548X
AutoresYukihiro Motoyama, M. Aoki, Naoki Takaoka, Ryuta Aoto, Hideo Nagashima,
Tópico(s)Chemical Synthesis and Reactions
ResumoThe combination of IrCl(CO)(PPh3)2 with 1,1,3,3-tetramethyldisiloxane or poly(methylhydrosiloxane) (PMHS) is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides; in particular, facile removal of silicone and iridium residues from the product can be achieved by the use of PMHS.
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